01 · OVERVIEW
What Is Hereditary Cancer?
About 5% to 10% of all cancers are hereditary, caused by an inherited genetic mutation (such as BRCA1, BRCA2, or mismatch repair genes) passed down through families. People who inherit these gene alterations have a significantly higher lifetime risk of developing specific cancers, often at a younger age.
Your genetic history does not define your future. Genetic testing and specialized counselling empower you to take control. As an AIIMS-trained medical oncologist in Jaipur, Dr. Rishabh Jain helps families identify genetic predispositions early, providing structured surveillance, preventive interventions, and mutation-targeted therapy options.
02 · GENETIC SYNDROMES
Common Hereditary Cancer Syndromes
Leading genetic conditions evaluated and managed at Rishabh Cancer Care:
Hereditary Breast & Ovarian Cancer (HBOC)
Caused by mutations in BRCA1, BRCA2, PALB2, or ATM genes, increasing risk of breast, ovarian, and prostate cancers.
Lynch Syndrome (HNPCC)
Mutations in MLH1, MSH2, MSH6, or PMS2 genes causing increased predisposition to colorectal, uterine, and stomach cancers.
Familial Adenomatous Polyposis (FAP)
APC gene mutation causing hundreds of pre-cancerous polyps in the colon from young adulthood.
Li-Fraumeni & Cowden Syndromes
Rare hereditary conditions linked to TP53 and PTEN genes associated with early sarcomas, brain, and thyroid tumours.
03 · CANDIDACY
Who Should Consider Genetic Counselling?
Genetic evaluation is recommended if you or your family members meet any of the following criteria:
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Breast, ovarian, or colon cancer diagnosed before the age of 50.
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Multiple close family members (on same side of family) with related cancers.
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A single family member diagnosed with more than one separate cancer (e.g., breast and ovarian).
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Triple-Negative Breast Cancer (TNBC) or High-Grade Serous Ovarian Cancer at any age.
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Male breast cancer in a family member.
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A known hereditary cancer gene mutation already detected in a blood relative.
Family Safety: Identifying an inherited mutation allows your healthy siblings and children to be tested (cascade testing) to protect their long-term health.
04 · TESTING WORKFLOW
Our Genetic Counselling & Testing Process
A supportive, confidential 4-step genetic oncology workflow:
1. Pre-Test Counselling
Dr. Jain constructs a 3-generation family tree (pedigree) to assess genetic probability and explain test implications.
2. Simple Sample Collection
A quick, painless blood draw or saliva sample collected in our clinic without any special preparation.
3. High-Depth NGS Testing
DNA sequenced in accredited genomics laboratories covering multi-gene hereditary cancer panels.
4. Post-Test Consultation
Results explained with compassionate clarity, distinguishing between pathogenic mutations and benign variants.
5. Personalized Prevention Plan
Customized screening schedules (annual MRI breast, early colonoscopy) created for mutation carriers.
6. Targeted Drug Selection
For existing cancer patients, BRCA-positive status unlocks targeted PARP inhibitors (Olaparib, Talazoparib).
05 · PREVENTION
Actionable Risk-Reduction Strategies
Testing positive for a gene mutation allows us to implement proven preventive measures:
| Preventive Strategy |
Clinical Action & Benefit |
| Intensive Early Screening |
Annual Breast MRI + Mammogram starting at age 25–30; Colonoscopy every 1–2 years from age 20–25. |
| Chemoprevention |
Medications like Tamoxifen or oral contraceptives to significantly lower future breast/ovarian risk. |
| Risk-Reducing Surgeries |
Prophylactic salpingo-oophorectomy (after childbearing) reduces ovarian cancer risk by up to 90%. |
| Targeted Therapy Selection |
Direct selection of precision PARP inhibitor tablets for cancer patients with germline BRCA mutations. |
If your family history shows early-onset or repeated cancers, genetic screening can save lives through early detection and proactive prevention. Consult Dr. Rishabh Jain today.
06 · FINANCIAL CLARITY
Hereditary Genetic Testing Cost in Jaipur
Technological advances in Next-Generation Sequencing (NGS) have made genetic testing highly affordable in India:
Focused Gene Panels
BRCA1 & BRCA2 complete gene sequencing at transparent, accessible pricing.
Comprehensive Multi-Gene Panels
Simultaneous screening of 30 to 50+ hereditary cancer genes for thorough peace of mind.
Cascade Family Testing
Once a mutation is found in a patient, family members can test for the specific gene at very low cost.
One-Time Lifetime Test
Your inherited genetic DNA never changes; testing is done only once in a lifetime.
Pre & Post Test Guidance
Includes complete pre-test pedigree mapping and post-result clinical consultation.
Digital Report Sharing
Secure electronic genomic reports provided with national genetic registry standards.
Confidential & Secure: All patient genetic data and family pedigree records are kept strictly confidential and protected by ethical medical standards.
